S.C. Const. art. VII, § 2

Section of old county to be cut off. If two-thirds of the qualified electors voting at such election shall vote “Yes” upon such questions, then the General Assembly at the next session shall establish such new County: Provided, No section of the County proposed to be dismembered shall be thus cut off without consent by a two-thirds vote of those voting in such section; and no County shall be formed without complying with all the conditions imposed in this Article. An election upon the question of forming the same proposed new County shall not be held oftener than once in four years.